Manchester United host Manchester City on Saturday with the Etihad side looking to close the gap between them and table toppers Arsenal.
United have won eight games in a row and could equal their longest winning run in all competitions since Alex Ferguson retired as manager in 2013.
Second-placed City, who are four points above United, lost to Southampton in the Carabao Cup on Wednesday and must bounce back to put pressure on the gunners.
United manager Erik ten Hag says it will not a revenge mission after a 6-3 drubbing in the first leg at Etihad stadium.
“It was a lesson, we took the lesson and from that point on we have made huge progress so we have to continue the progress,’ Ten Hag said of the teams’ last meeting.” Erk said.
“That game was a setback, we can all find reasons why but it is always about having to act, to deliver.” he added.
United are closing in on the loan signing of Burnley striker Wout Weghorst but he will not be eligible to play because he would have needed to be registered by 12:00 GMT on Friday.
Anthony Martial is a doubt with a leg injury, so in-form Marcus Rashford, who has scored seven goals in his last six games, could play as a centre-forward.
City will be without England defender John Stones, who has a fitness issue and also missed their surprise midweek cup defeat by the Premier League’s bottom team.
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